Juha Hulmi

Academy of Finland Research Fellow (2014-2019)

Education

2004     MSc: Exercise physiology (University of Jyväskylä, Finland)

2009     PhD: Exercise physiology (University of Jyväskylä, Finland). PhD Thesis

2013    Docent: Exercise physiology (University of Helsinki, Faculty of Medicine)

Past:

2005-2009 Doctoral Student

2010-2013 Academy of Finland Post Doctoral Researcher

Contact information

Faculty of Sport and Health Sciences

Neuromuscular Research Center

Biology of Physical Activity

University of Jyväskylä

Viveca 235, P.O. Box 35

40014 Jyväskylä, Finland

E-mail: juha. hulmi  (at) jyu.fi

Second Affiliation

Faculty of Medicine (Physiology)

University of Helsinki

Main research interests

• Muscle hypertrophy
• Muscle atrophy/wasting/cachexia
• Sports nutrition
• Exercise physiology
• Muscle metabolism and signaling
• Strength training
• Muscle medicine
• Weight loss / fitness

Selected recent publications (others, see Pubmed):

As a PI or post doc

Nissinen T, Hentilä J ... Hulmi JJ. Treating cachexia using sACVR2B-Fc improves survival, alters mTOR localization and attenuates liver and spleen responses. Journal of Cachexia Sarcopenia Muscle. In press: May 2018:

https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12310

Hentila J, Ahtiainen JP ...  Hulmi JJ. Autophagy is induced by resistance exercise in young men but unfolded protein response is induced regardless of age. Acta Physiology. In press April 2018.

Hulmi JJ, Nissinen T ... Kivelä R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. J Cachexia Sarcopenia Muscle. 9, 417-432, 2018,

Puolakkainen ... Hulmi JJ, Kiviranta R. Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy. BMC Musculoskelet Disord. 18, 2017.

Hulmi JJ ... Häkkinen K. The effects of intensive weight reduction on body composition and serum hormones in female fitness competitors. Frontiers in Physiology January 10 2017.

Hulmi JJ, Hentilä J, ... Atalay M. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radical Biology & Medicine 99:308-322, 2016.

Nissinen TA ... Hulmi JJ. Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Scientific Reports 6, 2016.

Räsänen M., … Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A. 2016 113(46):13144-13149.

Juha J. Hulmi... Heikki Peltonen. The effects of whey protein with or without carbohydrates on resistance training adaptations. J Int Soc Sports Nutr. 12, 48, 2015.

Ahtiainen J, … Hulmi JJ, Häkkinen K. Resistance Training-Induced Adaptations in Muscle Size and Strength are Heterogeneous. Age 38, 10, 2016.

Kainulainen H, ... Juha J. Hulmi. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology 2015 399, 131-142.

Holopainen T, … Hulmi JJ…, Kivelä R, Alitalo K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2015 Oct 1. pii: 201517810.

Ahtiainen JP, ... Hulmi JJ. Exercise type and volume alters signaling pathways regulating skeletal muscle glucose uptake and protein synthesis European Journal of Applied Physiology 115: 1835-1845, 2015.

Silvennoinen M, Ahtiainen JP, Hulmi JJ… Kainulainen H. PGC‐1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise. Physiological reports 3, e12563, 2015

Paulsen, G, ... Hulmi JJ,... Raastad T.Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. Journal of Physiology 15;592(Pt 24):5391-408 2014.

Rita Rinnankoski-Tuikka, Juha J. Hulmi, ... Heikki Kainulainen. Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change. Metabolism 63: 1031-40, 2014

Riikka Kivelä,... Juha J. Hulmi, ... Kari Alitalo. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol. Med. 6:307-21, 2014.

Juha J. Hulmi ...  Ritvos O. Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin blocked mdx mice. American Journal of Physiology - Endocrinology and Metabolism 2013: 305: E171-E182.

Juha J. Hulmi ... Olli Ritvos. Muscle protein synthesis, mTORC1/MAPK/Hippo signaling and capillary density are altered by blocking of myostatin and activins. American Journal of Physiology - Endocrinology and Metabolism 2013: 304: E41-50.

Satu Pekkala, Petri Wiklund, Juha J. Hulmi, ... Sulin Cheng. Are Skeletal Muscle FNDC5 Gene Expression and Irisin Release Regulated by Exercise and Related to Health? Journal of Physiology, 591: 5393-5400, 2013.

Heikki Kainulainen, Juha J. Hulmi, Urho M. Kujala. Potential Role of Branched Chain Amino Acid (BCAA) Catabolism in Regulating Fat Oxidation. Exercise & Sport Sciences Reviews 41: 194-200, 2013.

Juha J. Hulmi ... Heikki Kainulainen.  Altered REDD1, myostatin and Akt/mTOR/FoxO/MAPK Signaling in Streptozotocin-induced Diabetic Muscle Atrophy. American Journal of Physiology - Endocrinology and Metabolism 2012 302: E307-15

Selected papers as a PhD student:

Juha J. Hulmi, Vuokko Kovanen, Harri Selänne, William J. Kraemer, Keijo Häkkinen, Antti A. Mero. Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37: 297-308, 2009.

Juha J. Hulmi, Juha P. Ahtiainen, Tuomas Kaasalainen, Eija Pöllänen, Keijo Häkkinen, Markku Alen, Harri Selänne, Vuokko Kovanen, Antti A. Mero. Post-exercise myostatin and activin IIb mRNA levels: effects of strength training. Medicine and Science in Sport and Exercise 39: 289-297, 2007.

Current main research projects

Academy of Finland 2014-2019. “Adequate muscle mass and aerobic capacity prolonging survival from muscle wasting: MassA”. I am investigating the extent and mechanisms how adequate muscle mass and aerobic capacity can prolong survival from a catastrophe situation (muscle wasting). https://www.jyu.fi/ajankohtaista/arkisto/2014/05/tiedote-2014-05-15-13-13-59-910255 and in english. See publications: 1, 2, 3, 4. 

Muscle protein homeostasis: Proteostasis 2015-2020: This study investigates the effects of exercise, hypertrophy and atrophy on muscle protein homeostasis. See publications: 1, 2 and: https://www.jyu.fi/en/news/archive/2018/04/tiedote-2018-04-06-15-04-05-638866

Fitness and weight reduction  2015-2019. "The effects of weight reduction on physiology and systems biology on fitness competitors." This study combines the skills from the experts of exercise and nutrition physiology, genetics, systems biology and sports psychology together. See publications: 1. 

Main research group in the Academy of Finland project:

A Group photo (23.8.2017) of my Academy of Finland project MassA. The Group is named "Another Group".

Juha Hulmi, PI (principal investigator)

Jaakko Hentilä, PhD student

Juulia Lautaoja, research assistant / PhD student

Tuuli Nissinen, PhD student

Anita Lampinen, Post doc

Mervi Tulonen, graduate student

Jarkko Järvinen, graduate student

Collaborators (2016-)

Riikka Kivelä, Docent

Olli Ritvos, Docent

Markus Perola, Professor

Heikki Sarin, PhD student

Mikko Kuokkanen, PhD

Fabio Penna, PhD

Heikki Kainulainen, Professor

Juha Ahtiainen, Docent

Mika Silvennoinen, PhD

Mustafa Atalay, Docent

Riccardo Ballaro, PhD student

Keijo Häkkinen, Professor

Antti Mero, Professor

Kari Alitalo, Professor

Markus Räsänen, MD, PhD student

Satu Pekkala, Docent

Petri Wiklund, PhD

Milan Sedliak, PhD

Truls Raastad, Professor

Maarit Lehti, PhD

Brad Schoenfeld, Professor

Henning Wackerhage, Professor

Lee Hamilton, PhD

Urho Kujala, Professor

Johanna Magga, PhD

Ville Isola, student, researcher

Kokkonen M, PhD

Tero Puolakkainen, PhD

Simon Walker, PhD

Heikki Peltonen, PhD

More information

For more information, see my scientific blog-page, Lihastohtori (in Finnish).

You can also follow me on Facebook, Google Scholar and LinkedIn and ResearchGate. Some of my appearances in media are listed here.

You should also check my recent Lihastohtori-book (In Finnish).