Juha Hulmi
Academy of Finland Research Fellow (2014-2019)
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Education2004 MSc: Exercise physiology (University of Jyväskylä, Finland) 2009 PhD: Exercise physiology (University of Jyväskylä, Finland). PhD Thesis 2013 Docent: Exercise physiology (University of Helsinki, Faculty of Medicine)
Past:2005-2009 Doctoral Student 2010-2013 Academy of Finland Post Doctoral Researcher
Contact informationFaculty of Sport and Health Sciences Biology of Physical Activity Neuromuscular Research Center University of Jyväskylä Viveca 235, P.O. Box 35 40014 Jyväskylä, Finland E-mail: juha. hulmi (at) jyu.fi
Second Affiliation Faculty of Medicine (Physiology) University of Helsinki
Main research interests
Selected recent publications (others, see Pubmed): As a PI or post doc Hulmi JJ, Nissinen T ... Kivelä R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. J Cachexia Sarcopenia Muscle. 2017 Dec 11 Puolakkainen ... Hulmi JJ, Kiviranta R. Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy. BMC Musculoskelet Disord. 18, 2017. Hulmi JJ ... Häkkinen K. The effects of intensive weight reduction on body composition and serum hormones in female fitness competitors. Frontiers in Physiology January 10 2017. http://journal.frontiersin.org/article/10.3389/fphys.2016.00689 Hulmi JJ, Hentilä J, ... Atalay M. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radical Biology & Medicine 99:308-322, 2016. Nissinen TA ... Hulmi JJ. Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Scientific Reports 6, 2016. Räsänen M., … Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A. 2016 113(46):13144-13149. Juha J. Hulmi... Heikki Peltonen. The effects of whey protein with or without carbohydrates on resistance training adaptations. J Int Soc Sports Nutr. 12, 48, 2015. Ahtiainen J, … Hulmi JJ, Häkkinen K. Resistance Training-Induced Adaptations in Muscle Size and Strength are Heterogeneous. Age 38, 10, 2016. Kainulainen H, ... Juha J. Hulmi. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology 2015 399, 131-142. Holopainen T, … Hulmi JJ…, Kivelä R, Alitalo K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2015 Oct 1. pii: 201517810. Ahtiainen JP, ... Hulmi JJ. Exercise type and volume alters signaling pathways regulating skeletal muscle glucose uptake and protein synthesis European Journal of Applied Physiology 115: 1835-1845, 2015. Silvennoinen M, Ahtiainen JP, Hulmi JJ… Kainulainen H. PGC‐1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise. Physiological reports 3, e12563, 2015 Paulsen, G, ... Hulmi JJ,... Raastad T.Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. Journal of Physiology 15;592(Pt 24):5391-408 2014. Rita Rinnankoski-Tuikka, Juha J. Hulmi, ... Heikki Kainulainen. Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change. Metabolism 63: 1031-40, 2014 Riikka Kivelä,... Juha J. Hulmi, ... Kari Alitalo. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol. Med. 6:307-21, 2014. Juha J. Hulmi ... Ritvos O. Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin blocked mdx mice. American Journal of Physiology - Endocrinology and Metabolism 2013: 305: E171-E182. Juha J. Hulmi ... Olli Ritvos. Muscle protein synthesis, mTORC1/MAPK/Hippo signaling and capillary density are altered by blocking of myostatin and activins. American Journal of Physiology - Endocrinology and Metabolism 2013: 304: E41-50. Satu Pekkala, Petri Wiklund, Juha J. Hulmi, ... Sulin Cheng. Are Skeletal Muscle FNDC5 Gene Expression and Irisin Release Regulated by Exercise and Related to Health? Journal of Physiology, 591: 5393-5400, 2013. Heikki Kainulainen, Juha J. Hulmi, Urho M. Kujala. Potential Role of Branched Chain Amino Acid (BCAA) Catabolism in Regulating Fat Oxidation. Exercise & Sport Sciences Reviews 41: 194-200, 2013. Juha J. Hulmi ... Heikki Kainulainen. Altered REDD1, myostatin and Akt/mTOR/FoxO/MAPK Signaling in Streptozotocin-induced Diabetic Muscle Atrophy. American Journal of Physiology - Endocrinology and Metabolism 2012 302: E307-15
Selected papers as a PhD student: Juha J. Hulmi, Vuokko Kovanen, Harri Selänne, William J. Kraemer, Keijo Häkkinen, Antti A. Mero. Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37: 297-308, 2009. Juha J. Hulmi, Jörgen Tannerstedt, Harri Selänne, Heikki Kainulainen, Vuokko Kovanen, Antti Mero. Resistance exercise and whey protein ingestion affects mTOR signaling pathway and myostatin in men. Journal of Applied Physiology, 106: 1720-1729, 2009.Juha J. Hulmi, Juha P. Ahtiainen, Tuomas Kaasalainen, Eija Pöllänen, Keijo Häkkinen, Markku Alen, Harri Selänne, Vuokko Kovanen, Antti A. Mero. Post-exercise myostatin and activin IIb mRNA levels: effects of strength training. Medicine and Science in Sport and Exercise 39: 289-297, 2007. Current main research projects
Academy of Finland 2014-2019. “Adequate muscle mass and aerobic capacity prolonging survival from muscle wasting: MassA”. I am investigating the extent and mechanisms how adequate muscle mass and aerobic capacity can prolong survival from a catastrophe situation (muscle wasting). https://www.jyu.fi/ajankohtaista/arkisto/2014/05/tiedote-2014-05-15-13-13-59-910255 and in english. First paper: http://www.nature.com/articles/srep32695 Muscle protein homeostasis: Proteostasis 2015-2020: This study investigates the effects of exercise, hypertrophy and atrophy on muscle protein homeostasis. First paper: https://www.ncbi.nlm.nih.gov/pubmed/27554968 Fitness and weight reduction 2015-2019. "The effects of weight reduction on physiology and systems biology on fitness competitors." This study combines the skills from the experts of exercise and nutrition physiology, genetics, systems biology and sports psychology together. First paper: http://journal.frontiersin.org/article/10.3389/fphys.2016.00689/abstract Main research group in the Academy of Finland project: A Group photo (23.8.2017) of my Academy of Finland project MassA. The Group is named "Another Group".
Juha Hulmi, PI (principal investigator) Jaakko Hentilä, PhD student Juulia Lautaoja, research assistant / PhD student Tuuli Nissinen, PhD student Anita Lampinen, Post doc
Mervi Tulonen, graduate student Jarkko Järvinen, graduate student
Current active collaborators Riikka Kivelä, Docent Olli Ritvos, Docent Markus Perola, Professor Heikki Sarin, PhD student Fabio Penna, PhD Heikki Kainulainen, Professor Juha Ahtiainen, Docent Mika Silvennoinen, PhD Mustafa Atalay, Docent Riccardo Ballaro, PhD student Keijo Häkkinen, Professor Antti Mero, Professor Kari Alitalo, Professor Markus Räsänen, MD, PhD student Satu Pekkala, Docent Ville Isola, student, researcher
More informationFor more information, see my scientific blog-page, Lihastohtori (in Finnish). You can also follow me on Facebook, Google Scholar and LinkedIn and ResearchGate. Some of my appearances in media are listed here. You should also check my recent Lihastohtori-book (In Finnish). |